A drive-by shooting has killed a woman in her 60s and left a suburban home peppered with bullet holes.

The killer remained on the run on Tuesday morning, with authorities hunting for the person behind the overnight attack in Ambarvale on Sydney’s southwest outskirts.

Shots were fired from an unknown vehicle at a house on Dickens Rd on Monday night where the 65-year-old woman was hit.

Emergency services were called to the property about 11pm and treated the woman, but she died at the scene.

Two other people in the home were not injured, a 21-year-old woman and a 34-year-old man.

Nearby resident Louise Hosar said she heard gunshots shortly after 10.30pm.

“Within 20 minutes I went to bed and my bedroom just lit up with the police lights …  they didn’t have the sirens going, but there was a lot of police presence and ambulances up there,” she told AAP.

“I woke my house up to alert them that something was happening … it was very distressing to hear the family, and shocking to find out she was an elderly lady.”

Local officers and the homicide squad are investigating, with a number of police vehicles outside the property as authorities begin their probe.

Police inspected bullet holes on the stairs leading to the property’s front door and on the front wall of the house.

At least three bullet holes could be seen on the house, while around 10 yellow evidence markers were spotted at the taped-off road as police hunt for the killer.

They also crawled to look underneath a P-plated car parked in the property’s driveway.

Along with the two uninjured occupants, police say members of the public will be key to their investigation and ask witnesses to contact Crimestoppers.

Ms Hosar, who has lived in the area for 18 years but did not know the dead woman, said the violence was “part of living on Dickens Rd”.

“Every few weeks there’s a lot of police presence,” she said.

“Dickens Rd always gets the negative (attention) but we do have some really nice people that live on Dickens Rd, and in Campbelltown in general.”