A woman has died and a man and two children have been taken to hospital after a house caught fire in Orange this morning.

Emergency services were called to the home on Pimpala Place about 5.45am, Saturday 3 June, and found the building well-alight.

A man had escaped the blaze but suffered burns when attempting to re-enter the home.

Officers from Fire and Rescue NSW entered the building and rescued two children; they were treated at the scene by NSW Ambulance paramedics suffering the effects of smoke inhalation. The three are now in Orange Base Hospital.

A short time later, firefighters located a woman in the front room; however, she was unable to be revived.

All four are from the same family.

A crime scene has been established; specialist fire investigators and scene of crime officers will enter the building when it is deemed safe. As a consequence, the cause of the fire is yet to be determined.

Inquiries are now underway by detectives attached to Central West Police District.

Anyone with information about this incident is urged to contact Crime Stoppers: 1800 333 000 or https://nsw.crimestoppers.com.au.